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A Patient once administered with Adalimumab (TNF-alpha) for Crohn's disease. If one was still on Adalimumab,...

A Patient once administered with Adalimumab (TNF-alpha) for Crohn's disease. If one was still on Adalimumab, how might this have altered the course of the delayed hypersensitivity reaction?

A patient is undergoing allergic reaction from a tree and showed delayed hypersensitivity reaction. Then a patient took antihistamine. If a patient was still taking adalimumab, how might it have altered the course?

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Answer #1

Adalimumab is a subcutaneously administered disease modifier for the treatment of rheumatoid arthritis, chron's disease etc.

Adalimumab can cause delayed hypersensitivity reaction.

Delayed hypersensitivity is a common immune response occur through direct action of sensitized TCells when stimulated by an antigen. It requires 11-24hrs for showing the signs of inflammation.

Adalimumab can cause delayed hypersensitivity due to the rapid generation of anti adalimumab IgG Antibodies in the body.

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