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outline 3 reasons why the amino acid proline is not commonly found in alpha helices in...

outline 3 reasons why the amino acid proline is not commonly found in alpha helices in detailExplain each reason . 15 mks.

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Answer #1
  • In proline, the nitrogen atom is part of a rigid ring, and rotation about the N-Cbond is not possible. Thus, a Proline residue introduces a destabilizing kink in an helix.
  • The nitrogen atom of a Proline residue in peptide linkage has no substituent hydrogen to participate in hydrogen bonds with other residues. For these reasons, proline is only rarely found within an helix.
  • The range for Proline residues is greatly restricted because is limited by the cyclic side chain to the range of -35o to -85o.The rigid cyclic side chain of proline occupies the space of a neighboring residue of the helix and disrupts the helical structure.
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