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What are the causes and DNA repair mechanisms for each type of mutation: 1. Base Substituition...

What are the causes and DNA repair mechanisms for each type of mutation:

1. Base Substituition

Cause:

DNA repair mechanism:

2. Thymine Dimers

Cause:

DNA repair mechanism:

3. Indels

Cause:

DNA repair mechanism:

4. Nucleotide expansion

Cause:

DNA repair mechanism:

5. Larger lesions (duplications, deletions, inversions, translocations)

Cause:

DNA repair mechanism:

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Answer #1

1. Base substitution : Cause = Replication error,Point mutation

DNA repair mechanism = Missmatch repair

2. Thymine dymers : Cause = UV light

Repair mechanism = photoreactivation and excision repair

3. Indels : Cause = NHEJ recombination, improper cross over

Repair mechanism = CRISPER

4. Nucleotide expansion:Cause = Error in replication and repair

Repair mechanism = Base excision repair

5. Larger lesions:Cause - Replication error and recombination

Mechanism = Nucleotides excision repair  

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