Question

Eleven-year-old Harry is complaining of a severe sore throat and gets to stay home from school. His pediatrician prescribes a course of broad-spectrum antibiotics, and Harry feels much better within a few days. However, some two weeks later, Harry has a dull, bilateral pain in his lower back and his urine is a smoky brown color.

a. Based on the symptoms described, what is Harry’s condition?

b. How is this related to his sore throat?

c. Why is his urine a smoky brown color?

d. What treatment is recommended for this condition?

Answer 1

a. Henery is having acute poststrptococcal glomerulonephritis (PSGN)

b. Sore throat is causef by Beta haemolytic streptococcus. Molecular mimicry and formation of Immunoglobulin which deposit on Glomerular basement membrane combines with antigen of GBM and activate complement system.

c. SMOKY URINE - is suggetive of haematuria due to Glomerulonephritis.

d. Treatment - Manegement of hypertension by antihypertensive is the mainstay of treatment. Antibiotics containing penicillin is recommended for 10 days to contain the spred of infection.

Calcium channel blockers, ACE inhibitors and Vasodilator bare the mainstay antihypertensive for this.