When oxygen combines with hemoglobin in the blood it forms oxy-hemoglobin and it helps in transport of oxygen to different parts of the body where the oxygen then dissociates from the oxy-hemoglobin and enters the cells.
The oxygen-hemoglobin saturation/dissociation curve depends upon temperature, pH and Bi-phosphoglyceric acid (BPG).
When the temperature increases then more readily oxygen dissociates from hemoglobin due to which oxygen gets released from oxy-hemoglobin and enters the cells of the tissues.
When the pH decreases then more readily oxygen dissociates from hemoglobin due to which oxygen gets released from oxy-hemoglobin and thus enters the body cells.
When the concentration of BPG increases then more readily oxygen dissociates from hemoglobin due to which oxygen gets released from oxy-hemoglobin and oxygen enters the cells.
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