Question

GF00Z is a novel drug that blocks glucose transporters in hepatocytes, meaning that these cells are less able to absorb glucose. What might be a functional consequence of taking GF00Z, both on the small scale of the hepatocytes themselves, but also on a larger, body wide scale? Briefly explain your answers.

Answer 1

Upon blocking the glucose transporters, glucose present in bile will not be reabsorbed in intrahepatic bile ducts.There will be disruption in osmotic gradient which won't allows the movement of water from bile therefore more biles.

Consequences of taking GF00Z can be on small sclae of hepatocytes as well as on body scale -

1.fasting hypoglycemia

2.post prandial hyperglycemia

3.elevated cholesterol level

4.hepato renal glycogen accumulation leads to hepatomegaly.

5.PCT renal dysfunction

6.Dwarfism