You’ve created a new drug to treat COVID. It is a hydrophilic drug that is about the same size as tyrosine and needs to get inside epithelial cells of the lungs. Which one of the following statements would be true of this drug?
these epithelial cells would need a lot of protein channels to get this drug inside
assuming there is a very high concentration of drug in the blood compared to epithelial cells, this drug would move into these cells through active transport
it would be important to know that there was no competitive inhibition by any substances in the body before administering the drug
it would bind to plasma membrane receptors to cause its effects on these cells
Ans:- C) it would be important to know that there was no competitive inhibition by any substances in the body before administering the drug.
concept:- Lipid-derived (soluble)or hydrophilic drugs can enter the cell by diffusing across the plasma membrane and binding to DNA to regulate gene transcription and to change the cell's activities by inducing production of proteins that affect, in general, the long-term structure and function of the cell.
Option a) is wrong because protein channel is not required to transport hydrophilic drug.
b) wrong because it is absorbed by diffusion.
D) it is hydrophobic so doesn't act on plans membrane receptor.
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