Question

give two examples (one exercise and one non-exercise) that would lead to the complete depletion of muscle and liver glycogen stores

Answer 1

Exercise example is high intensity exercise and marathons. Cardio vascular wise, sprint intervals, hill repeats are effective for glycogen depletion. During exercise body will convert glycogen into glucose which helps in contraction of muscles, acts as primary fuel source. Intense physical exercise leads to lactate accumulation and glycogen depletion in working muscle, indicating high rate of glycolysis.

Non exercise glycogen depletion example is lack of food or starvation. Glucagon stimulates glycogen breakdown and triggers cyclic AMP cascade by inhibiting glycogen synthesis leading to phosphorylation and phosphorylase activation and glycogen synthase inhibition.