Question

The new coronavirus has been spreading around the world. It causes more than three hundred thousand infected and more than fifteen thousand dead. One of the coping with the virus is to find new effective drugs. In order to design a new antiviral drug, we have to consider the binding affinity of the drug molecule and target proteins of the virus for inhibit the specific function of the proteins. Which thermodynamics function is related to the binding affinity? Explain.

Answer 1

Solution :

The thermodynamic function related to binding energy is Gibbs free emergy. The binding affinity is determined by the Gibbs energy of binding (ΔG) which is the sum of enthalpic (ΔH) and entropic (-TΔS) contributions. Because the enthalpy and entropy contribute in an additive way to the binding energy, the same binding affinity can be achieved by many different combinations of enthalpic and entropic contributions.

Wish you all the best buddy please upvote it ?