Question

The new coronavirus has been spreading around the world. It causes more than three hundred thousand infected and more than fifteen thousand dead. One of the coping with the virus is to find new effective drugs. In order to design a new antiviral drug, we have to consider the binding affinity of the drug molecule and target proteins of the virus for inhibit the specific function of the proteins. Which thermodynamics function is related to the binding affinity? Explain.

Answer #1

Solution :

**The thermodynamic function related to binding energy is
Gibbs free emergy. The binding affinity is determined by the Gibbs
energy of binding (ΔG) which is the sum of enthalpic (ΔH) and
entropic (-TΔS) contributions. Because the enthalpy and entropy
contribute in an additive way to the binding energy, the same
binding affinity can be achieved by many different combinations of
enthalpic and entropic contributions**.

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