Question

6. Which of the following inflammatory mediators cannot achieve the given effect?

The Mediator​​​​​​​Effect

a. Bradykinin​​​​​​Pain

b. Prostaglandins​​​​​Vasodilatation

c. Oxygen metabolites​​​​​Vasoconstriction

d. Chemokines ​​​​​​Leukocyte activation

e. IL-1 ​​​​​​​Endothelial activation

Answer 1

e, IL-1 endothelial activation
Factors involved in delay sustained response IL-1; interleukin. dealyed sustained responded is observed in endothelial cells in cytoskeletal changes that take 4 to 6 hours after mediator stimulation and last for the day. IL-1 is an inflammatory mediator act directly on human vascular endothelial cells to alter the functional property.
Bradykinin is a peptide that promotes information. ACE inhibitors increase bradykinin level by inhibiting degeneration and increase vasodilatorion and vascular permeability of some vessels. chronic inflammation tissue degeneration mediated by nitrogen species, protease, reactive o2 species, infiltrated inflammatory cells that increase the vaso dilation and vascular permeability.