Question

A 34-year-old Hispanic-American male with end-stage renal disease received kidney transplant from a cadaver donor, as no one in his family was a good match. His post-operative course was uneventful, and he was discharged with the antirejection drugs Tacrolimus (Prograf), Cyclosporine (Neoral), and Imuran (Azathioprine). He did well for 3 months and had returned to his job as a policeman. Six months after his transplant, he began to gain weight, had decreased urine output, was very fatigued, and began to run temperatures up to 101˚F. He was evaluated by his nephrologist, who diagnosed acute kidney transplant rejection.

Develop a 1- to 2-page case study analysis in which you:

• Explain why you think the patient presented the symptoms described.
• Identify the genes that may be associated with the development of the disease.
• Explain the process of immunosuppression and the effect it has on body systems.

Answer 1

Rejection occurs most often in the first six months after the transplant. African Americans are at increased risk of graft failure. The race is an important factor affecting the graft and patient survival in kidney transplant recipients. increases immunological response to the allograft causes more rate of graft loss in Hispanic Americans. Immunological responses cause inflammation changes in allograft due to the recipient's immune system recognizing foreign antigen in the allograft.
LIMS 1 genes in all the reciepents with genes deletion who has transplant rejection common among people of European and African desent. genomic incompatibility between donor and recipients causes allosensitization against new antigens that recessive inheritance of gene disrupting variance causes allograft rejection. when a kidney transplant is done our body knows that the new kidney act as a foreign. out body try to attack the new kidney and damage that. Immunosuppressants help to suppress the body able to do this, it prevents rejection and minimize the side effects of the drugs.