Question

The reaction starts at room temperature but what will happen to the temperature over time? why could this be a problem in an industrial or manufacturing setting?(an exothermic reaction)

Answer 1

This reaction
is moderately exothermic, posing a problem for conventional industrial scale manufacturing,
while flow chemistry is known to be advantageous for such processes due to high heat
transfer capabilities.
The Paal-Knorr reaction was translated from conventional batch processing into continuous
flow chemistry without any major issues. The kinetic parameters reaction time and reagent
ratio were controlled by flow rates. These reaction parameters, together with temperature,
were then screened fully automated to find optimal conditions