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What is an example of a disorder that is caused by some sort of "turning on"...

What is an example of a disorder that is caused by some sort of "turning on" OR "turning off" of a regulatory gene in a Eukaryotic cell?

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Answer: Mutations in HoxD13 in humans can cause a genetic condition called synpolydactyly, in which people are born with extra fingers or toes that may also be fused together.

Gene expression is defined as processes that control the turning on or turning off of a gene. The Hox genes are a set of transcription factor genes that exhibit an unusual property: They provide a glimpse of one way in which gene expression is translated into the many different forms that animals (metazoans) exhibit. For the most part, the genome seems to be a welter of various genes scattered about randomly, with no order present in their arrangement on a chromosome—the order only becomes apparent in their expression through the process of development.

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