Question

There are key intermediates in the TCA cycle. Draw the structures of:

•Citrate (Is this where the cycle gets its name?)

•Oxaloacetate

•Succinyl CoA (don’t worry about the CoA part)

•The first symmetrical substrate (and name it!)

Answer 1

Krebs cycle is also called citric acid cycle or tricarboxylic acid cycle occurs in the matrix of mitochondria and enzymes of Krebs cycle present in the matrix of mitochondria except for Suucinate dehydrogenase. In Krebs cycle, one acetyl coenzyme A combine with one molecule of oxaloacetate and produces citrate. The citrate is the first product produced in Krebs cycle so it is also called as a citric acid cycle. During Krebs cycle, two carbons are released as a CO₂ and one GTP, one FADH₂, three NADH₂ are produced from one molecule of acetyl coenzyme A. Succinate is the first symmetrical substrate of Krebs cycle.