Question

For the essay, students will compare the pathogenesis of Leishmaniasis (L. tropia minor and L. t. major, L. braziliensis, L mexicana and L. donovani) and Chagas disease (Trypanosoma cruzi). Specific features of tissue changes and destruction, characteristic appearance of affected tissue, tissue and organs involved and virulence/invasiveness should be discussed. I have all of the info attached to this link under essay, but I'm not sure how to make it an essay. please help. https://1drv.ms/w/s!AsxRZFzXBFZWhXDmOrkswblE8Bx-

Pathogenesis is the mechanism through which an infection causes disease or the production as well as developement of disease.A parasitic disease Leishmaniasis is caused by the Leishmania type. It is transmited by the bite of definite types of sandflies. This disease can occur in three forms that are cutaneous form that is demonstrate with skin ulcers, mucocutaneous form that is manifest with skin, nose and mouth ulcers, or visceral leishmaniasis present with ulcer of skin and then later develope with fever, low red blood cells, also enlarged spleen and liver. L. tropica and L. major are the species causing the Old World form of cutaneous leishmaniasis in the Middle east, Africa, Asia, Mediterrenean and India. An intracellular pathogen L. tropica and L. major that infects the macrophages as well as dendritic cells of the immune system and their incubation period differ from few days to many months. Initially there is a small symptom of an infection, red papule at bite site that may end in a few weeks, but generally thin crust is develops that conceal a spreading ulcer below. In many places cutaneous leishmaniasis is also called as 'oriental sore' i.e. more than 2 or 3 ulcers combine to produce large sore maybe recover within a few months to a year or may present into a secondary infection. A heterogeneous species L. Tropica is a strain complex that can be differentiated on serologic, biochemical and ecological grounds. Zoonotic L. tropica is a dogs parasite and rodents and is related with rural disease. Anthroponotic L. tropica is a human parasite and arise in urban environments.A protozoan endoparasite Leishmania/ tropica, inhabiting in skin of human causing cutaneous leishmaniasis

Answer 1

• Leishmaniasis is caused by parasite Leishmania donovani , Leishmania tropica and L. braziliensis.
• Leishmania donovani causes visceral leishmaniasis which results in ulcer of skin and it later develops into enlarged spleen, liver. It causes diseases such as kala azar, dumdum fever.
• Leishmania tropica cause cutaneous leishmaniasis which shows skin ulcers. It causes Delhi ulcer.
• L. braziliensis cause mucocutaneuous leishmaniasis which results in skin, nose and mouth ulcers. It causes Uta, chiclero ulcer.
• Leishmania tropica is a heterogenous strain and shows varieties such as L.t.major, L.t.minor and L.t.ethiopica.
• L.tropica and L.major are the species causing old world form of cutaneous leishmaniasis.
• Old world form could be seen in Middle East, Africa, Asia, mediterrenean and India.
• L.viannia brazilienis forms part of new world of central America and south America.