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Explain how net filtration pressure behind the GFR is determined. Describe the influence hydrostatic pressure has...

Explain how net filtration pressure behind the GFR is determined. Describe the influence hydrostatic pressure has on GFR?

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Answer #1

Glomerular filtration is driven by the pressure that builds in these capillaries. Several factors leading and affecting this pressure is.

  • The diameter of afferent arterioles that bring blood in the glomerulus is larger than efferent arterioles that take away the blood. This difference leads to a pressure build-up called glomerular hydrostatic pressure which is 60 mm
  • The hydrostatic pressure by the capsules oppose it - capsular hydrostatic pressure = - 18 mm
  • The colloidal osmotic pressure due to proteins like albumin also oppose = -32 mm

Hence a sum of these pressures, resultant +10 mm is the net filtration pressure

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