Question

The researchers also identified a number of chemokines and complement components that were upregulated due to...

The researchers also identified a number of chemokines and complement components that were upregulated due to IFNg treatment. Choose one; identify its function and its anti-viral properties.

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005263

Homework Answers

Answer #1

a number of chemokines (CXCL9, CXCL10, CCL8 and CXCL11) and complement components (C1s and C1r) were also highly upregulated by IFNγ

CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, suggesting an underlining pathophysiological relation between levels of these chemokines and the development of adverse cardiac remodeling.[6][7]

This chemokine has also been associated as a biomarker for diagnosing Q fever infections.

It has anti-viral property against Ebola virus(EBOV)

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