Question

Which of the following genes is not expressed in the Hindlimb but is expressed in the...

Which of the following genes is not expressed in the Hindlimb but is expressed in the Forelimb in proximal-distal development?

Group of answer choices

a. Hox 13

b. Hox 12

c. Hox 9

d. Hox 11

e. Hox 10

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Homework Answers

Answer #1

The bones of any tetrapod limb—be it arm or leg, wing or flipper—consist of a proximal stylopod (humerus/femur) adjacent to the body wall, a zeugopod (radiusulna/tibia-fibula) in the middle region, and a distal autopod (carpals-fingers/tarsalstoes). Homeobox transcription factors, or Hox genes, is the most crucial gene which play an essential role in specifying whether a particular mesenchymal cell will become stylopod, zeugopod, or autopod. Hox9 and Hox10 paralogues specify the stylopod. If we mutated the Hox10 paralogues, the femur will not generate, but the humerus will be expressed in the fore limb but not in the hind limb of stylopod because the hind limb does not express the Hox9 paralogues.

So, the Hox9 gene is not expressed in the Hindlimb but is expressed in the Forelimb in proximal-distal development.

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