Question

is it true that Deviations from neutral pH will alter the charge and shape of enzymatic molecules

Answer 1

Answer: The given statement true.
Explanation:
Proteins are heteropolymers of amino acids linked together by peptide bonds. Each amino acid contains an amino group, a carboxyl group, and an R-group. The R-groups of many amino acids are ionizable i.e. the charge on R-groups varies with the pH of the solution. The nature of the R-group determines the overall structure of the protein and in turn its function. If the pH of the solution changes, the charge on the R-group also changes. As a result, the interactions of the amino acid with other amino acids alter leading to the denaturation of the protein.

Hence, each protein exhibits a specific pH range in which it exhibits optimum function.