Question

The philosopher and theologian Soren Kierkegaard wrote that we define ourselves bychoices we make. It seems the embryo already knows this.a) What is considered to be the first binary decision in mammalian development?b) What is the second major decision within mammalian development?b) How and when during mammalian development do cells decide to retain or forfeitpluripotency? (***Provide the core transcriptional pathways for the pluripotency ofEmbryonic Stem cells).

Answer 1

ANSWER:-

A).

The first binary decision in mammalian development is the segregation of the trophectoderm from the inner cells mass followed by the separation of the inner cell mass into the epiblast and the primitive endodem.

B).

Inner cell mass cells coexpress the lineage - associated transcription factors Nanog and Gata6, which later mark the epiblast and the primitive endoderm, respectively.

C).

Mammalian cells whether retain or forfeit pluripoency depends on the POU Transcription factor Oct4. Activity of Oct4 is essential for the identity of the pluripotrntial founder cell population in the mammalian embryo. Oct4 deficient cells will retain.

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