Question

The famous -10 and -35 DNA sigma factor binding motifs function as? A. DNA sequence landmarks that ensure proper sigma favor binding to promoter regions, and as a result bring along RNA polymerase to park at a position enabling transcription at position +1. B. the -10 motif binds inducers (e.g., Cap/cAMP) and -35 motif binds a repressor (e.g., LacI). C. DNA sequence landmarks that interact directly with RNA polymerase placing the transcription initiation at position +1. D. transcription repressors, preventing RNA polymerase to bind to the promoter region

Answer 1

The famous -10 and -35 DNA sigma factor binding motifs function as - A

A- DNA sequence landmarks that ensure proper sigma favor binding to promoter regions, and as a result bring along RNA polymerase to park at a position enabling transcription at position +1.

-10 and -35 region is called as consensus sequence(promoter sequence) it is essential for transcription initiation. After binding of sigma factor at -10 and -35 sequences close DNA becomes open DNA complex and transcription is initiated at +1 position.