Scientists recently discovered a ubiquitous bacterial species that appears to have rapidly acquired the ability to produce a toxin very similar to botulinum. How could a bacterium undergo such a rapid genetic change? From an evolutionary standpoint, what advantage would this new capability (botulinum) potentially confer on the bacterium?
Genetic exchanges among bacteria occur by several mechanisms. In
transformation, the recipient bacterium takes up extracellular
donor DNA. In transduction, donor DNA packaged in a bacteriophage
infects the recipient bacterium. In conjugation, the donor
bacterium transfers DNA to the recipient by mating.
Clostridium botulinum is found in soil and untreated water
throughout the world. It produces spores that survive in improperly
preserved or canned food, where they produce a toxin. When eaten,
even tiny amounts of this toxin can lead to severe
poisoning.Botulinum toxin type A is well tolerated in the treatment
of chronic pain disorders
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