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Pyruvate dehydrogenase (PDH) kinase 1 (PDK1) phosphorylates and inhibits PDH and thusly increases citrate production for...

Pyruvate dehydrogenase (PDH) kinase 1 (PDK1) phosphorylates and inhibits PDH and thusly increases citrate production for lipid synthesis.

True or False

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Answer #1

PDH converts the pyruvate to acetyl CoA. Acetyl CoA is the building blocks for the lipid synthesis. If production of Acetyl CoA is reduced then citric acid production also decreases. Citric acid doesn't produce the fatty acids. Hence the fate of Acetyl CoA is to enter citric acid cycle or to enter lipid synthesis. Hence if the PDK1 phosphorylated and inhibits the PDH then acetyl CoA production is decreased. Hence the statement given in the question is false because inhibition of PDH doesn't increase citric acid production and also citric acid is also not used for lipid synthesis.

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