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Inhibitors of pyruvate dehydrogenase kinase have been proposed as potential treatment for type 2 diabetes, which...

Inhibitors of pyruvate dehydrogenase kinase have been proposed as potential treatment for type 2 diabetes, which is characterized by high blood levels of glucose due to insulin resistance. Suggest a biochemical rationale for this proposal.

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The pyruvate dehydrogenase kinase has been proposed as potential treatment for type 2 diabetes, which is characterized by high blood levels of glucose due to insulin resistance.

The pyruvate dehydrogenase kinase up- and down-regulates the activity of the pyruvate dehydrogenase complex (PDC), which is required to maintain the steady-state concentration of ATP during the feed-fast cycle and efficient utilization of fatty acid and glucose. PDC converts pyruvate, coenzyme A (CoA), and NAD+ into acetyl-CoA, NADH and carbon dioxide.

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