Question

1. Cancer-causing mutations in RB1, the retinoblastoma gene, leads directly to:

   		Amplification of epidermal growth factors
   		Targeting of p53 for degradation
   		Excessive rounds of DNA synthesis
   		Increase in telomerase activity
   		None of the above proto-oncogene

Answer 1

answer - option no c is correct which state that the cancer causing mutation in the rb1 lead to the excessive rounds of the dna sythesis

because as rb is a tumor supressor protein which keep the transcription factor E2F in check when it is not phosphorylated while when the rb is phosphorylated or mutated it cant keep the E2F in check and E2F is free being a transcription factor it cause the expression of gene which code for cell cycle proliferation or dna replication protein