Question

Jane is given an experimental drug X. This drug is a cholinergic blocking agent. It is a type of blocking agent that prevents acetylcholine from attaching to any of its receptors in the autonomic effectors. This drug has many different effects on Jane. Determine which of the following statements are true or false based on the above information.

1. The muscle cells in the walls of the bronchioles relax.

2. Reduced ability to focus on close objects.

3. Increased salivation.

4. Reduced ability to contract the diaphragm.

Answer 1

1. True --> Acetylcholine causes bronchial smooth muscles constriction, hence anticholinergic drug will lead to relaxation of bronchial muscles.

2. True-->Topical instillation of anticholinergic causes mydriasis, abolition of light reflex and cycloplegia lasting 7–10 days. This results in photophobia and blurring of near vision.

3. False --> Acetylcholine causes Secretion from all parasympathetically innervated glands is increased via M3 and M2 receptors: sweating, salivation, lacrimation, increased tracheobronchial and gastric secretion, so anticholinergic drug will decrease the Secretion

4. True---> ACh causes increased contraction of diaphragm, hence anticholinergic drug will decrease the contraction.