Question

1. Coffee (even decaffeinated coffee) is a stimulus for gastrin release by stomach cells. One effect of drinking coffee is that it stimulates mass movements within the colon. Using your knowledge gained from this chapter, make a hypothesis as to how this effect most likely takes place.

2. Xenical (or Orlistat) is a drug that acts as a reversible lipase inhibitor. It exerts its action by forming a covalent with the active site of gastric and pancreratic lipases. The therapeutic administration of this drug is indicated for the treatment of morbid obesity. How might this drug be useful in such instance? Specifically, what effect does it have on the body?

3. Refer to the question above. If you were a doctor who prescribed orlistat for one of your patients, what potential side effects or concerns might you have regarding this treatment?

Answer 1

1.caffeine is a pro-motility agent, meaning that it encourages contraction of the muscles that help pass food through the digestive tract. This could cause cramping

2.XENICAL (orlistat) is a gastrointestinal lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats. it works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged.

3.most comon side effects include Bladder pain,body aches,chills ,cough ,diarrhea,difficulty with breathing ,ear congestion ,fever.

other side effects include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge.