Question

why do we have both NK cells and CTL that both target cancerous and virally infected...

why do we have both NK cells and CTL that both target cancerous and virally infected cells ?

Science   Anatomy-And-Physiology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

NK cells are mostly known for killing of tumor cells as well as virus infected cells. They do not need any priming by antigen presenting cellsas required in cytotoxic t cells which also take part in killing of virus infected cells and cancer cells. Nk cells are always on a natural patrol and when they sense cells with activating signals, they respond to them .

Normal cells have MHC I receptors on their surface which marks them as self and priduce inhibitory signals for Nk cells to have a check on them. Whereas cancer and virus infected cells lose the mhc 1 receptors being vulnerable to nk cells which further release perforins and granzymes for the killing of target cells.

Cytotoxic t lymphocytes kill the target cells by releasing cytokines and making way to apoptosis.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
why are NK cells suck an important componet of the immune system?
why are NK cells suck an important componet of the immune system?
Natural killer cells target infected cells through: a.T cell receptors that recognize MHC-peptide complexes. b. Fc...
Natural killer cells target infected cells through: a.T cell receptors that recognize MHC-peptide complexes. b. Fc receptors that recognize bound antibodies on the surface of infected cells c. Integrin molecules that bind bacteria surface. d. None of the above.
Cancer cells do not respond normally to cues that regulate growth. As a result, cancerous cells...
Cancer cells do not respond normally to cues that regulate growth. As a result, cancerous cells grow and divide uncontrollably, requiring large amounts of nucleotides to support their high rate of nucleic acid synthesis and NADPH for the synthesis of fatty acids and for cell survival under stress conditions. Considering glycolysis, gluconeogenesis and the pentose phosphate pathway, describe the flow of glucose 6-phosphate to address the needs of cancerous cells.
(A) In thinking about viruses, (i) Gram positive bacteria and plant cells are not readily infected...
(A) In thinking about viruses, (i) Gram positive bacteria and plant cells are not readily infected by enveloped viruses. Why? (ii) Explain why viruses do not infect spores.   (iii) Explain the following statement: "Antiviral chemicals have to target or prevent the early replication steps of a viral infection."
We have an illness, where 2% of the polulation is infected, and we have a test...
We have an illness, where 2% of the polulation is infected, and we have a test with sensitivity 94% and specificity 98%. A="infected" and B="tests positive" Question: 20 people gets tested, and all tests negative. What is the probability that atleast one of these 20 really are infected?
Answer the following question thoroughly: Why do we need only one primer to target a highly...
Answer the following question thoroughly: Why do we need only one primer to target a highly dissimilar region, and not both primers?
We have an illness, where 2% of the polulation is infected, and we have a test...
We have an illness, where 2% of the polulation is infected, and we have a test with sensitivity 94% and specificity 98%. A="infected" and B="tests positive" The question: What is the probability that a test-subject tests positive, even when not infected? And how high does the specificity need to be such that the probability is below 10%
You are working in a lab that is studying immune responses to highly pathogenic influenza A...
You are working in a lab that is studying immune responses to highly pathogenic influenza A virus infection. You have isolated antibodies from mice that were given a sub-lethal dose of virus. When these antibodies are intravenously transferred into naive recipient mice, the recipient mice immediately show resistance to what would otherwise be a lethal dose of the virus, and this immunity lasts 1-2 weeks. In experiments to investigate the mechanism underlying this effect, you find to your surprise that...
Which statement about hormones, hormone-producing cells, and target cells is true? a. Cells in close proximity...
Which statement about hormones, hormone-producing cells, and target cells is true? a. Cells in close proximity to hormone-producing cells are more strongly affected by the hormone than cells at a distance b. All hormones travel in the blood to target cells c. Target cells have receptors for binding the hormone they are a target for d. Endocrine glands have ducts that lead to the outside of the body e. Endocrine cells do not exist as single cells within a tissue
We have the following statements: 1 percent of the population is infected by a disease. We...
We have the following statements: 1 percent of the population is infected by a disease. We have a test, a, that has a sensitivity of 90% and a specificity of 95%. Sensitivity means that a person will test positive IF they are in fact infected. Specificity means that a person will test negative IF they are in fact not infected. The question is: What is the probability that a random tested person gets a positiv result? And what is the...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT