Question

Consider Mintz's (1980) study on possible birth defects in children born to mothers who have used benedictine. The study, reported to the Food and Drug Administration by Dr. Herschel Jick of the Boston Drug Surveillance Program, was done in collaboration with the Group Health Cooperative of Puget Sound, Washington.  

The survey included 2966 mothers who used the drug in pregnancy and 4663 mothers who did not. Six relatively severe limb disorders were found in each group. Carry out a test of possible association between the use of benedictine by mothers and birth defects in children. Calculate 95% confidence limits of the measure of association.

Answer 1

using excel>addin>phstat>confidence interval

we have

Confidence Interval Estimate for the Proportion
Data
Sample Size	4663
Number of Successes	2966
Confidence Level	95%
Intermediate Calculations
Sample Proportion	0.636071199
Z Value	-1.95996398
Standard Error of the Proportion	0.007045769
Interval Half Width	0.013809453
Confidence Interval
Interval Lower Limit	0.622261746
Interval Upper Limit	0.649880651

95% confidence limits of the measure of association is (0.6223 ,0.6499)