Question

# Treatment with statins can reduce the risk of a major cardiovascular event in people with specified...

Treatment with statins can reduce the risk of a major cardiovascular event in people with specified risk factors. During about 2 years of follow-up in the JUPITER trial, 142 of 8901 subjects treated with a statin had a major cardiovascular event.

1)First, estimate the 2-year risk, and give a 95% confidence interval for this estimate. Assuming that risk remains constant over time, give an estimate of the 10-year risk of a major cardiovascular event on statin therapy.

2)Suppose the expected 2-year risk of a major cardiovascular event in similar but untreated people is 0.028. Test whether the 2-year risk in those treated with a statin is significantly different from this expected risk at the 5% level. Make sure to state your null and alternative hypotheses and specify your conclusion.

1. The 95% confidence interval for this estimate is between 0.013 and 0.019.

2. The hypothesis being tested is:

H0: p = 0.028

Ha: p ≠ 0.028

The test statistic is -6.89.

The p-value is 0.0000.

Since the p-value (0.0000) is less than the significance level (0.05), we can reject the null hypothesis.

Therefore, we can conclude that the 2-year risk in those treated with a statin is significantly different from this expected risk.

 Observed Hypothesized 0.016 0.028 p (as decimal) 142/8901 249/8901 p (as fraction) 142. 249.228 X 8901 8901 n 0.002 std. error -6.89 z 5.61E-12 p-value (two-tailed) 0.013 confidence interval 95.% lower 0.019 confidence interval 95.% upper 0.003 margin of error

Please give me a thumbs-up if this helps you out. Thank you!

#### Earn Coins

Coins can be redeemed for fabulous gifts.