Question

Epidemiology

4.5. Cole and MacMahon (1971) present the data given below from a case-control study of bladder cancer:

High-risk Occupation?	High cigarette Consumption?	No. of cases	No. of controls
No	No	43	94
No	Yes	173	189
Yes	No	26	20
Yes	Yes	111	72

(i) Calculate the odds ratio for bladder cancer comparing high-risk to other occupations (ignoring cigarette consumption).

(ii) Test the null hypothesis that the odds ratio is the same for those who work in high-risk and in other occupations.

(iii) Calculate the Mantel-Haenszel odds ratio for high-risk versus other occupations,adjusted for cigarette consumption.

(iv) Test the null hypothesis that the smoking-adjusted odds ratio is one.

(v) Interpret the results.

Answer 1