Question

Drug X has just received FDA approval for lowering the low-density lipoprotein cholesterol (LDL-C) in adults. You would like to design a clinical trial to see whether the new drug is effective in your pediatric population. To gather some preliminary evidence, you have measured the LDL-C in children who have been treated with drug X at baseline and after 3 months of therapy and observed the data to be normally distributed. You next objective is to compare the baseline LDL-C with the LDL-C collected after administering drug X for 3 months. Which one of the following statistical tests would be best if the goal were to maximize the likelihood of avoiding a type II error?

Group of answer choices

Paired student t-test.

Wilcoxon signed rank

ANOVA

Chi-square.

Answer 1

Solution:

A paired t test is used when we are interested in the difference between two variables for the same subject.

Often the two variables are separated by time . However something the two variables are separated by something other than time.

In the given example we have to measured the lipoprotein cholesterol levels (LDL- C) in children who have been treated with drug X at baseline. And after 3 months therapy we are interested to compare the baseline LDL-C with LDL -c collected after administering drug X for 3 months.

Paired student t test is used.

Option A is correct.