Question

Question 5

Cystic fibrosis (CF) is a recessive gene disease meaning that a child has to inherit a defective CF gene from each parent. This means that there is a 25% chance of a child having cystic fibrosis if both parents are CF carriers Hence the number of children with CF (in a family whose parents are CF carriers) has a binomial distribution with n = the number of children in the family and p= 0.25

i. In a family of four (4) children whose parents are CF carriers, what is the probability that exactly one (1) of the children has cystic fibrosis. (2 mark)

ii. In a family of six (6) children whose parents are CF
carriers, what is the probability that one or more of the children
has cystic fibrosis.

Answer #1

Question 5
Cystic fibrosis (CF) is a recessive gene disease meaning that a
child has to inherit a defective CF gene from each parent. This
means that there is a 25% chance of a child having cystic fibrosis
if both parents are CF carriers Hence the number of children with
CF (in a family whose parents are CF carriers) has a binomial
distribution with n = the number of children in the family and p=
0.25
i. In a family...

If we denote a cystic fibrosis gene with a c and a disease-free
gene with a C (since the disease is recessive), then only a cc
person will actually have the disease. Such persons would
ordinarily die before parenting children, but a child can also
inherit the disease from two Cc parents (who themselves are
healthylong dash—that
is, have no symptoms but are "carriers" of the disease).
Suppose a child is born to one cystic fibrosis carrier parent
and one...

The Autosomal Recessive disease, Cystic Fibrosis (CF),
runs in Jill’s family. Jill is unaffected. Based on this data,
select which of the following statements could be True?
A.
If Jill’s Paternal Aunt is affected and her Paternal
Grandparents are unaffected. There is a 2/3 probability her father
is a Carrier
B.
In the future, Jill’s parents have another child and
that child has CF. Therefore, her parents have a 100% probability
of being Carriers
C.
Jill could never produce a...

The Autosomal Recessive disease, Cystic Fibrosis (CF), runs in
Jill’s family. Jill is unaffected. Based on this data, select which
of the following statements could be True?
A.
If Jill’s Paternal Aunt is affected and her Paternal
Grandparents are unaffected. There is a 2/3 probability her father
is a Carrier
B.
In the future, Jill’s parents have another child and that child
has CF. Therefore, her parents have a 100% probability of being
Carriers
C.
Jill could never produce a...

Cystic fibrosis (CF) is an autosomal recessive disease. In a
South American country, a study was conducted to test the
hypothesis that cystic fibrosis carriers were less likely to be
affected and die from by tuberculosis (TB) infection. To begin the
quantitative study, researchers needed to identify the number of
individuals in the population that were carriers, knowing the
frequency of the cystic fibrosis allele was 0.1 in the population.
After their analysis, the researchers concluded that there was
evidence...

Cystic fibrosis is one of the most common autosomal recessive
disorders. The carrier frequency in a general population is 1/25. A
woman who knows she is heterozygous for the mutation that causes
cystic fibrosis (CF) marries a man with no family history of CF at
all. What is the probability that they will produce a child that
has cystic fibrosis?
Suppose the couple above has a child with cystic fibrosis. What
is the chance that their second child will have...

Cystic fibrosis is one of the most common autosomal recessive
disorders. The carrier frequency in a general population is 1/25. A
woman who knows she is heterozygous for the mutation that causes
cystic fibrosis (CF) marries a man with no family history of CF at
all. What is the probability that they will produce a child that
has cystic fibrosis? Suppose the couple above has a child with
cystic fibrosis. What is the chance that their second child will
have...

Cystic fibrosis (CF) is an autosomal recessive disease. In a
South American country, a study was conducted to test the
hypothesis that cystic fibrosis carriers were less likely to be
affected and die from by tuberculosis (TB) infection. To begin the
quantitative study, researchers needed to identify the number of
individuals in the population that were carriers, knowing the
frequency of the cystic fibrosis allele was 0.1 in the population.
After their analysis, the researchers concluded that there was
evidence...

Cystic fibrosis is an autosomal recessive disorder. Beth and Tom
do not have cystic fibrosis but each have a sibling with cystic
fibrosis. Beth's parents and Tom's mother do not have the disease.,
but Tom's father does. Calculate the probability that if this
couple has a child, the child will NOT have cystic fibrosis.

Cystic fibrosis (CF) is a genetic disorder that affects mostly
the lungs, but also the pancreas, liver, kidneys, and intestine. CF
is inherited in an autosomal recessive manner with simple Mendelian
inheritance. It is caused by the presence of mutations in the gene
for the cystic fibrosis transmembrane conductance regulator (CFTR)
protein.
A normal couple intends to have children but consult a genetic
counselor because the man has a sister with CF and the woman has a
brother with CF....

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