Question

Zoloft is a drug used to treat obsessive-compulsive disorder (OCD). In randomized, double-blind clinical trials, 926 patients diagnosed with OCD were randomly divided into two groups. Subjects in group 1 (experimental group) received 200 milligrams per day (mg/day) of Zoloft, while subjects n group 2 (control group) received a placebo. Of the 553 subjects in the experimental group, 77 experienced dry mouth as a side effect. Of the 373 subjects in the control group, 34 experienced dry mouth as a side effect. Do a higher proportion of subjects experience dry mouth who are taking Zoloft versus the proportion taking the placebo? Use the α = 0.01 level of significance. Use the p-value approach.

State the requirements to perform this test:

Perform a Hypothesis Test:

Answer #1

Zoloft is a drug used to treat obsessive-compulsive disorder
(OCD). In randomized, double-blind clinical trials, 926 patients
diagnosed with OCD were randomly divided into two groups. Subjects
in group 1 (experimental group) received 200 milligrams per day
(mg/day) of Zoloft, while subjects n group 2 (control group)
received a placebo. Of the 553 subjects in the experimental group,
77 experienced dry mouth as a side effect. Of the 373 subjects in
the control group, 34 experienced dry mouth as a...

In randomized, double-blind clinical trials of a new vaccine,
subjects were randomly divided into two groups. Subjects in group 1
received the new vaccine while subjects in group 2 received a
control vaccine. After the first dose, 107 of 724 subjects in the
experimental group (group 1) experienced fever as a side effect.
After the first dose, 60 of 641 of the subjects in the control
group (group 2) experienced fever as a side effect. Construct a
95% confidence interval...

In? randomized, double-blind clinical trials of a new? vaccine,
infants were randomly divided into two groups. Subjects in group 1
received the new vaccine while subjects in group 2 received a
control vaccine. After the first? dose, 102 of 746 subjects in the
experimental group? (group 1) experienced vomiting as a side
effect. After the first? dose, 66 of 619 of the subjects in the
control group? (group 2) experienced vomiting as a side effect.
Construct a 95?% confidence interval...

In? randomized, double-blind clinical trials of a new? vaccine,
children were randomly divided into two groups. Subjects in group 1
received the new vaccine while subjects in group 2 received a
control vaccine. After the first? dose, 118 of 746 subjects in the
experimental group? (group 1) experienced fever as a side effect.
After the first? dose, 51 of 623 of the subjects in the control
group? (group 2) experienced fever as a side effect. Construct a
99?% confidence interval...

In randomized, double-blind clinical trials of a new vaccine,
children were randomly divided into two groups. Subjects in group 1
received the new vaccine while subjects in group 2 received a
control vaccine. After the first dose, 101 of 744 subjects in the
experimental group (group 1) experienced vomiting as a side
effect. After the first dose, 60 of 635 of the subjects in the
control group (group 2) experienced vomiting as a side effect.
Construct a 99% confidence interval...

In randomized, double-blind clinical trials of a new vaccine,
monkeys were randomly divided into two groups. Subjects in group 1
received the new vaccine while subjects in group 2 received a
control vaccine. After the first dose, 114 of 722 subjects in the
experimental group (group 1) experienced fever as a side effect.
After the first dose, 71 of 609 of the subjects in the control
group (group 2) experienced fever as a side effect. Construct a 99
% confidence...

In clinical trials of the allergy medicine Clarinex (5 mg), it
was reported that 50 out of 1655 individuals in the Clarinex group
and 31 out of 1652 individuals in the placebo group experienced dry
mouth as a side effect of their respective treatments.
Test the hypothesis that a greater proportion of individuals in
the experimental group experienced dry mouth compared to the
individuals in the control group at the level of 5%
significance.
Null Hypothesis:
Alternate Hypothesis:
P-value:
Conclusion:...

Researchers conducted a randomized, double-blind study to
measure the effects of the drug olanzapine on patients diagnosed
with bipolar disorder. A total of 115 patients with a DSM-IV
diagnosis of bipolar disorder were randomly divided into two
groups. Group 1 (n1 = 55) received 5 to 20 mg per day of
olanzapine, while group 2 (n2 = 60) received a placebo.
The effectiveness of the drug was measured using the Young–Mania
rating scale total score with the net improvement in...

A test is conducted in order to find if there is a difference at
the α=0.01 level of significance. In some randomized, double-blind
clinical trials of a new vaccine, children were randomly divided
into two groups. Subjects in group 1 received the new vaccine while
subjects in group 2 received a control vaccine. After the first
dose, 67 of 607 subjects in the experimental group (group 1)
experienced fever as a side effect. After the first dose, 109 of
728...

In clinical trials of a medication, 2128 subjects were divided
into two groups. The 1585 subjects in group 1 received the
medication. The 543 in group 2 received a placebo. Of the 1585
subjects in group 1, 50 experienced dizziness as a side effect. In
group 2, 17 experienced dizziness as a side effect. To test
whether the proportion experiencing dizziness in group 1 is greater
than that in group 2, the researchers entered the data into
statistical software and...

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