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Do you think that using a significance level of is appropriate for all experiments? In the...

Do you think that using a significance level of is appropriate for all experiments? In the early stages of research and development work is there a lot of harm in identifying a factor as important when it really is not? Would that seem to justify higher levels of significance such as $\alpha = 0.10$ or perhaps even $\alpha = 0.15$ in some situations?

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