Artery disease. An article in the New England Journal of Medicine describes a randomized controlled trial that compared the effects of using a balloon with a special coating in angioplasty (the repair of blood vessels) compared with a standard balloon. According to the article, the study was designed to have power 90%, with a two-sided Type I error of 0.05, to detect a clinically important difference of approximately 17 percentage points in the presence of certain lesions 12 months after surgery.13
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