Question

Consider two genes with different expected mutation rates due to size. Gene 1 has a mutation rate of 1 x 10-6 in the population, while gene 2 has a mutation rate of 3 x 10-6 in the population. Assume that the probability for an individual to have two mutations in one gene is 0. Also, the number of bases, n, in a gene is large.

1. State the probability that there are more than two people with mutations total between the two genes in your sample.

2. Consider the case that gene 2 controls the potential for mutation of gene 1. If gene 2 is mutated, gene 1 has a probability of 50% of being mutated, while if gene 2 is not mutated, gene 1 has a probability of 10% of being mutated. What is the probability that gene 1 is mutated in an individual.

Answer 1