Question

1. Multiple myeloma, or blood plasma cancer is characterized by increased blood vessel formulation (angiogenesis) in the bone marrow that is a predictive factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient’s own stem cells. The data in the table below represent the bone marrow micro-vessel density for patients who had a complete response to the stem cell transplant and at the time the complete response was determined.

Patient	Before	After
1	258	284
2	189	314
3	202	101
4	353	227
5	416	290
6	426	176
7	441	190

At the 0.05 level of significance, is there evidence that the mean bone marrow micro-vessel density is

higher before the stem cell transplant than after the stem cell transplant?    Show all work please

Answer 1