Question

1. Refer back to your data set from homework 3b. The objective was to test the effectiveness of the drug lonafarnib. PWV was measured on the 18 children before taking the drug, then re-measured on the same children after receiving a daily dose of the drug for two years. The drug is considered effective if the difference in PWV between before and after is at least 5. Please see HW3b data, where “untreated” = before taking the drug, and “treated” = after taking the drug for two years.

untreated	treated
18.8	12.6
17.6	10.8
17.5	10.1
16	10.1
14.8	9.2
14.1	7.6
13.7	10.8
13.1	7.7
12.9	6.8
12.9	7.5
12.4	9.4
10.1	6.4
9.3	9
9.1	6.2
8.3	7.2
7.9	7.3
8.3	5.7
7.2	9.1

1. Report the null and alternate hypotheses for a sign test
2. Report the number of positive and negative signs (remember this is based on a hypothesized difference of 5)
3. Report the P value and test statistic, do you accept or reject the null hypothesis?
4. Use a signed-rank test to re-run the analysis above.

Answer 1

1: Sign Test:

2: Sign Rank Test: