Question

what " cuts to the core of evidence based medicines"?

Answer 1

When a clinical trial research is carried out using medicines, it may so happen that during this research, both positive and negative results may occur. But the laboratory carrying out this research may suppress the negative results and only publish/reveal the positive results. It would then make sense that these kinds of researches are registered based on their methodologies so that the results are independently confirmed by experts. The laboratories should emphasize on thinking about different methods and hypothesis testing (evidence-based) and should ignore the pressure of producing fast, positive results. Here, the problem of suppression of negative results during the clinical trial period cuts to the core of evidence-based medicines.