Question

Scientists enrolled 212 couples with one partner heterozygous for Huntington’s disease (an autosomal dominant disorder) and who had four children. The children were genetically tested for the Huntington’s allele and the following results were compiled from the family data:

Number of families	hh/Hh children
10	All hh
37	3 hh, 1 Hh
87	2 hh, 2 Hh
62	1 hh, 3 Hh
16	all Hh

Perform a chi square analysis to determine whether their observations matched their expectations (that Huntington’s Disease is caused by a dominant allele of a single gene).

Answer 1