Question

Genotype	TT	CT	CC
Control	30	50	20
Case	20	60	20

In a genotype-phenotype association study for a human disease, the following contingency table is given for a SNP (two alleles C and T). Using a Chi-square test, test whether this SNP is a significant marker for the underlying phenotype, given a level of significance 0.05. [ 30 marks]

Answer 1