The probability of flu symptoms for a person not receiving any treatment is 0.037. In a clinical trial of a common drug used to lower cholesterol, 39 of 983 people treated experienced flu symptoms. Assuming the drug has no effect on the likelihood of flu symptoms, estimate the probability that at least 39 people experience flu symptoms. What do these results suggest about flu symptoms as an adverse reaction to the drug?
Answer:
X ~ Bin(n,p)
Where n = 983 , p = 0.037
Mean = np = 983 * 0.037 = 36.371
Standard deviation = sqrt (np(1-p))
= sqrt ( 983* 0.037 ( 1 - 0.037) )
= 5.9182
Using normal approximation,
P(X < x) = P(Z < ( x - Mean ) / SD)
With continuity correction ,
P(X >= 39) = P(Z > (38.5 - 36.371) / 5.9182)
= P(Z > 0.35)
= 1-P(Z<0.35)
=1 - 0.6368
= 0.3632
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