Question

You are investigating the association between anti-depression medication during pregnancy and malformations in newborn infants. Your study participants will be the next 200 singleton births occurring at the New York Presbyterian Hospital. For each birth, women are asked about their medication history. You review medical charts to verify whether women were taking anti-depression medications during their pregnancy. Of the 200 women in your study, 40 mothers have taken anti-depression medications. Of these women, 35 have delivered malformed infants. Among women who did not take anti-depression medications, 10 have delivered malformed infants.

Based on this information, fill in the 2x2 table.

Anti-depression medication during pregnancy		Malformations in newborn infants		Total
		D+	D-
E+
E-
	Total			200

Answer 1

Solution:

We are given that there are total 40 mothers who have taken anti-depression medications and out of these, 35 have delivered malformed infants, therefore, 5 of these women have not delivered malformed infants.

Also, there will be 200 - 40 = 160 mothers who have not taken anti-depression medications and out of these, 10 have delivered malformed infant, therefore, 150 of these women have not delivered malformed infants.

Therefore, the table can be filled as: