Question

There is some research that suggests that various penicillins applied directly to the    brain inhibit glutamic acid decarboxlase (GAD).

            a) Describe a few behavioral/medical effects resulting from application of these penicillins.

            b) Which drug might you prescribe as an ‘antidote’ to accidental intracranial penicillin application? Briefly Explain.

Answer 1

a) The application of penicllin directly to the brain leads to perform less socially, one prefers to be alone then. It also decreases anxiety like behaviours.

Meanwhile some pencillins can increase agression and reduce social avoidance.

It increases cytokine expression in both the sexes and the integrity of the blood brain barrier changes.

B) Anithistamines work well to withdraw from penicllin and if any allergy caused by Penicillin. Silibinin is the treatment of choice in Europe as anitdote to pencillin but this has not been apporved in the United States.