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1.Explain the dopamine theory of schizophrenia. What are its deficiencies? Explain the alternative (or complementary) explanations...

1.Explain the dopamine theory of schizophrenia. What are its deficiencies? Explain the alternative (or complementary) explanations that are available.

2.Describe the monoamine hypothesis for depression; include the evidence for it and a description of the effects of the drugs and ECT used to treat it.

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Answer #1

1. Dopamine hypothesis of schizophrenia: It is a model attributing symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The main support for the theory comes from the observation that consuming too much dopamine causes schizophrenia. The antipsychotic medications which are used to treat schizophrenia block dopamine receptors. The medications are designed to bind to dopamine receptors in the brain, and their effects have helped many people cope with symptoms.

It is proposed that the increased dopamine function suggested by the dopamine hypothesis of schizophrenia is a dopaminergic postsynaptic receptor supersensitivity resulting from a dopamine deficiency.

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