Question

4. Which of the following are somatodendritic autoreceptors for glutamate?

a. mGluR1,5

b. mGluR2,3

c. mGluR4,7,8

d. AMPA

e. NMDA

Answer 1

The correct answer is (d) AMPA and (e) NMDA

Explaination is as follows-

Meaning of Glutamate- Glutamate is a neurotransmitter that sends signals to the brain and nerves. It plays a significant role in the development of brain but increased quantity of glutamate leads to several dangerous diseases like Parkinson's disease,Alzheimer,stroke etc. The biochemical receptors of Glutamate are has three major types as AMPA, NMDA and metabotropic glumate receptors.

AMPA- AMPA receptors are specialized for excitation and also known as ionotropic receptors. They generally produce excitatory responses after stimulation.

NMDA- NMDA are also ionotropic receptors but they are different from AMPA. The properties of NMDA make them important for learning and memory. NMDA receptors are found intracellulary in the somatodendritic compartments of various cell types.