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THE FOLLOWING DATA was obtained on the initial rate of binding glucose to enzyme hexokinase.the rate...

THE FOLLOWING DATA was obtained on the initial rate of binding glucose to enzyme hexokinase.the rate law for this reaction is v0= k[glucose]a[hexokinase]a.prove the reaction follows pseduo first order and calculate the second order rate constant if the order with respect to hexokinase is 1.the concentration of hexokinase is 1.34mmol.dm3

[glucose]a (mmol.dm3) v0(dm3.mol.s-1)
1 5
1.54 7.61
3.12 15.5
4.02 20
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Answer #1

The reaction of interest is : ....

The rate law is assumed to have the form

In the method of initial rates, this rate law becomes

There are two ways to go about this problem, taking simple ratios and graphically.

1) For each possible combination of experiments, construct the ratio of the initial rates:

For the other combinations:

AVG order with respect to glucose ...

The effective 1 sts order rate constant is obtained by subsitution for each combination, AVG k = 4920 ....( assumes the enzyme is in excess)

2) For a graphical (better) solution. After fitting to a straight line, the slope will be x and the y- intercept will correspond to INk.

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