Can quarks change flavor through lepton exchange?
No, quarks cannot change flavour through lepton exchange, because leptons are not exchange particles. Leptons are not exchanged in any interaction.
Quarks can change flavour in a weak interaction in which leptons may be involved but W bosons are exchanged in such an interaction, not leptons.
For example, consider beta-plus decay process:
here one quark changes its flavour from up (u) to down (d). And there are leptons (positron and electron-neutrino) involved but the leptons are not what is exchanged. A W+ boson is exchanged in the beta plus decay. Here is the Fyneman diagram of the beta-plus decay:
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