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Sort the following changes to the DNA sequence for a gene in order from most likely...

Sort the following changes to the DNA sequence for a gene in order from most likely to be harmful to its function to least likely. Explain your reasoning.
(i) Insertion of a single extra base near the beginning of the gene.
(ii) Removal of a single base near the beginning of the gene.
(iii) Removal of three adjacent bases in the middle of the gene.
(iv) Substituting one base for another in the middle of the gene.

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